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Abstract: Molecular recognition abilities of molecularly imprinted polymers of 3-indolepropionic acid (P(IPA)) and 3-indolybutyric acid(P(IBA)) were prepared using 3-indolepropionic acid and 3-indolybutyric acid as template molecule, respectively, 4-vinylpyridine(4-Vpy) as functional monomer, ethyleneglycol dimethacrylate(EGDMA) as cross-linker and acetonitrile as porogen by bulk non-covalent imprinting technique. The molecular recognition performances were evaluated by high performance liquid chromatography. The results showed that both P(IPA) and P(IBA) exhibited molecular recognition ability for IPA and IBA, respectively, in the mobile phase of acetonitrile. The affinity and specificity of the two polymers reduced in acetonitrile/HAc mobile phase, which proved that electrostatic interaction played an important role in the molecular recognition processes. In addition, the comparison of molecular recognition ability was made among P(IPA),P(IBA) and P(IAA), which was synthesized under the same conditions as P(IPA) and P(IBA) except for the template molecule. The imprinting factors(IF) were larger than 6.00, 4.27 and 2.28 for IAA, IPA and IBA, respectively, in acetonitrile mobile phase, i. e. the imprinting efficiency decreased with the increase of the carbon-number in the indole-3-carboxylic chain. The study confirmed that there were cavities with the shape and orientation of the functional groups complementary to those of IPA and IBA, respectively, in P(IPA) and P(IBA). And the molecular imprinting efficiency reduced with the decrease of the acidity of the indole-3-carboxylic acid
Template and target information: 3-indolepropionic acid, IPA, 3-indolybutyric acid, IBA, 3-indoleacetic acid, IAA
Author keywords: molecularly imprinted polymer, molecular recognition, high performance liquid chromatography, 3-Indoleacetic acid, 3-Indolepropionic acid, 3-Indolybutyric acid, imprinting efficiency