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Reference type: Journal
Authors: Prasad BB, Tiwari MP, Madhuri R, Sharma PS
Article Title: Enantioselective quantitative separation of d- and l-thyroxine by molecularly imprinted micro-solid phase extraction silver fiber coupled with complementary molecularly imprinted polymer-sensor.
Publication date: 2010
Journal: Journal of Chromatography A
Volume: 1217
Issue: (26)
Page numbers: 4255-4266.
DOI: 10.1016/j.chroma.2010.04.055
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4YYGH0V-4/2/8e0390a809666b52db91e097a5b844d9

Abstract: Thyroxine is a known disease biomarker which demands a highly sensitive and selective technique to measure ultratrace level with enantiodifferentiation of its optical isomers (d- and l-), in real samples. In this work, an approach of hyphenation between molecularly imprinted micro-solid phase extraction and a complementary molecularly imprinted polymer-sensor was adopted for enantioseparation, preconcentration, and analysis of d- and l-thyroxine. In both techniques, the same imprinted polymer, coated on a vinyl functionalized self-assembled monolayer modified silver wire, was used as the respective extraction fiber as well as sensor material. This combination enabled enhanced preconcentration of test analyte substantially so as to achieve the stringent limit [limit of detection: 0.0084 ng mL-1, RSD = 0.81%, S/N = 3 (d-thyroxine); 0.0087 ng mL-1, RSD = 0.63%, S/N = 3 (l-thyroxine)] of clinical detection of thyroid-related diseases, without any problems of non-specific false-positive contribution and cross-reactivity
Template and target information: Thyroxine, 3,5,3,5-tetraiodothyronine, T4, d-thyroxine, l-thyroxine
Author keywords: Molecularly imprinted micro-solid phase extraction silver fiber, Enantioseperation, d- and l-Thyroxine, Differential pulse anodic stripping voltammetry, Real sample analysis

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