Book title: Kirk-Othmer Encyclopedia of Chemical Technology
Publisher: John Wiley & Sons, Inc.
Abstract: Molecularly imprinted polymers (MIPs) are analytical materials that have widespread use for applications in the biomedical, analytical, chemical and biological sciences. Molecular imprinting is a process where a polymer, or other material, is formed around a template molecule. In this way, MIPs are tailored for specific recognition of the template molecule or related analogs and provide molecular recognition functions similar to antibodies and enzymes. Advantages of molecularly imprinted materials lie in the durability, relatively inexpensive cost, and ease of formation of network peptide polymers. This is in contrast to the problems of biomolecules that are unstable, generally expensive and often difficult and time consuming to obtain (usually from animal sources). Furthermore, the imprinted polymers are formed as network polymer solids that are predisposed for application as solid supports for HPLC, GC, sensors, and membranes. The robustness of the solid also affords stability in organic solvents, under harsh conditions such as heat or pressure, and gives MIPs a shelf life of many years. While the basic concepts of molecular imprinting are easy to understand, there are many important details that give further insight to obtaining the best performance in MIPs. This review covers many of these details and provides examples for greater insight into the method of molecular imprinting
Template and target information: Review - MIPs