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Reference type: Journal
Authors: Kantarovich K, Tsarfati I, Gheber LA, Haupt K, Bar I
Article Title: Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy.
Publication date: 2010
Journal: Biosensors and Bioelectronics
Volume: 26
Issue: (2)
Page numbers: 809-814.
DOI: 10.1016/j.bios.2010.06.018
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-50CDSJ2-1/2/c275a308642be4d2c0af1c925c14df1d

Abstract: Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6-12 μm in diameter. The monitoring of SERS spectra with a micro-Raman system enabled examining the uptake and release of the S-propranolol imprinting template and allowed imaging individual dots as well as multiple dots in an array, revealing the distribution of the imprinted polymer. This distribution was confirmed by atomic force microscopy, showing that even in dots of <300 nm thickness, corresponding to MIP volumes of 0.5 fl, significantly less than previously reported, the target analyte could be detected and identified. This study shows that nanolithography techniques combined with SERS might open the possibility of miniaturized arrayed MIP sensors with label-free, specific and quantitative detection
Template and target information: S-propranolol
Author keywords: molecularly imprinted polymer, Surface-enhanced Raman scattering, Nano-fountain pen

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