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Reference type: Journal
Authors: Kitahara KI, Yoshihama I, Hanada T, Kokuba H, Arai S
Article Title: Synthesis of monodispersed molecularly imprinted polymer particles for high-performance liquid chromatographic separation of cholesterol using templating polymerization in porous silica gel bound with cholesterol molecules on its surface.
Publication date: 2010
Journal: Journal of Chromatography A
Volume: 1217
Issue: (46)
Page numbers: 7249-7254.
DOI: 10.1016/j.chroma.2010.09.041
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-5125R58-4/2/3867050953e2195cb34e547524bc100f

Abstract: Monodispersed molecularly imprinted polymer particles selective for cholesterol were prepared by the copolymerization of styrene and divinylbenzene in the presence of template silica gel particles (particle size: 5 μm; pore size: 10 nm) functionalized with cholesterol on the surface, followed by dissolution of the cholesterol-bonded silica gel with a NaOH aqueous solution. Transmission and scanning electron micrographs of the molecularly imprinted polymer (MIP) particles revealed good monodispersity and porous structure. The MIP particles were packed into a high performance liquid chromatographic column, and its recognition ability of cholesterol was evaluated using cholesterol, cholesterol esters and fatty acid methyl esters by comparison with the non-imprinted polymer (NIP) particles prepared from styrene and divinylbenzene without cholesterol. The MIP particles showed a high affinity for cholesterol and cholesterol esters (K'MIP/K'NIP>5.7)
Template and target information: cholesterol
Author keywords: Monodispersed molecularly imprinted polymer particles, Template porous silica gel, HPLC, cholesterol


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