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Reference type: Journal
Authors: Neto JdRM, Santos WdJR, Lima PR, Tanaka SMCN, Tanaka AA, Kubota LT
Article Title: A hemin-based molecularly imprinted polymer (MIP) grafted onto a glassy carbon electrode as a selective sensor for 4-aminophenol amperometric.
Publication date: 2011
Journal: Sensors and Actuators B: Chemical
Volume: 152
Issue: (2)
Page numbers: 220-225.
DOI: 10.1016/j.snb.2010.12.010
Alternative URL: http://www.sciencedirect.com/science/article/B6THH-51R0737-6/2/8a70a7ce20b294dde4a44a194c226289

Abstract: Molecular imprinting technology is becoming a versatile tool for the preparation of tailor-made molecular recognition elements. This work investigates the performance of a hemin-modified molecularly imprinted polymer (MIP) used as an amperometric sensor for the detection of 4-aminophenol (4-APh). MIP particles were prepared by the precipitation polymerization method with hemin introduced as the catalytic center to mimic the active site of peroxidase. 4-APh was used as the template molecule, methacrylic acid (MAA) as the functional monomer, trimethylolpropane trimethacrylate (TRIM) as the cross-linker and 2,2'-azobisisobutyronitrile (AIBN) as the initiator. The synthesized polymer particles were characterized in terms of particle size, porosity and morphology. The amperometric sensor used for 4-APh detection was prepared by modifying a glassy carbon electrode surface with the hemin-based MIP. Under optimized operational conditions, a linear response was obtained in the range of 10.0-90.0 μmol L-1, with a sensitivity of 5.5 nA L μmol-1 and a detection limit of 3.0 μmol L-1. The sensor showed good repeatability (RSD = 2.7% for n = 7). It exhibited to be very selective for 4-APh even in the presence of structurally similar compounds (2-aminophenol, catechol, guaiachol, 2-cresol and chloroguaiachol). Recoveries in the range 93-111% were obtained using the sensor for the determinations of 4-APh in tap and river water samples
Template and target information: 4-aminophenol, 4-APh
Author keywords: 4-Aminophenol, amperometric sensor, hemin, molecularly imprinted polymer

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