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Reference type: Conference Proceeding
Authors: Levi L, Srebnik S
Publication date: 2008
Article title: Structural characterization of protein-imprinted gels using lattice Monte Carlo simulation.

ISBN: 978-081691050-2
Conference information: Proceedings of the 2008 AIChE Annual Meeting

Abstract: Molecular imprinting finds relevance and importance in a range of applications including the development of new chemical sensors, separation technologies, and selective binding particularly for catalytic and bioreactors. While molecular imprinting technology has found success when imprinting small molecules, progress in molecular imprinting of biomacromolecules, such as polypeptides and proteins, is hindered, in part due to their large size and complex functionality. Unlike with small molecules, imprinting of biomacromolecules results in poor performance of the imprinted gel, characterized by significant nonspecific binding of molecules of similar shape and size to the template. Our research in this field aims to characterize the structure of protein-imprinted gels in an effort clarify the effects that lead to poor protein imprinting
Template and target information: Protein
Author keywords: Molecular imprinting: proteins, Monte Carlo, polymer gel, simulation


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