Authors: Pavlyuchenko VN
, Ivanchev SS
, Primachenko ON
, Khaikin SYa
, Danilichev VF
, Proshina VS
, Trunov VA
, Lebedev VT
, Kul'velis Y
Polymer hydrogels with the memory effect for immobilization of drugs.
Publication date: 2011
Journal: Polymer Science Series A
Abstract: Hydrogels with the memory effect are synthesized from crosslinked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate) via the method of template synthesis with the use of the drug cephazoline as a matrix. It is shown that the hydrogels show an increased sorption activity against the target drug and a slow rate of drug release from the hydrogel (the memory effect) under certain conditions. In combination with cephazoline, these hydrogels may be regarded as a new prolonged-drug-release system for the treatment of infectious diseases
Template and target information: cephazoline
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