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Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: Nalidixic acid imprinted polymer has a hig application in cilinical purposes. Molecularly imprinted polymers (MIPs) has been prepared using nalidixic acid as the template molecule. The polymer was synthesized in a non-covalent approach with N,NDimethylacrilamid (DMAA) and Allyl glycidil ether / imino diacetic acid (AGE/IDA) as the functional monomer, N,N methylene diacrylamid as the cross-linker in the methanol solution and 2,2'-azobis-isobutyronitril (AIBN) as the initiator. The polymerization was performed via a free radical. The synthesized MIP was identified by Fourier transform infrared (FT-IR) and thermo gravimetric analysis (TGA). The effect of various parameters like pH, adsorption time, amount of adsorbent and adsorption capacity of adsorbent at optimum conditions were considerd and followed by HPLC-UV analysis. Non-imprinted polymer (NIP) was also synthesized in the absence of the template compound. Batch adsorption experiments were used to evaluate the binding affinity of the imprinted polymer. It was confirmed that the binding ability of the prepared MIP for nalidixic acid was essentially sufficient in the presence of the other compounds coexisting in serum sample. It was demonstrated that this MIP could be applied to direct enrichment and determination of nalidixic acid from tablet matrix and human plasma
Template and target information: Nalidixic acid