MIPdatabase
Authors: Mahabadi M, Sadeghi HB, Panahi HA, Oskouei M
Publication date: 2011
Article title: Synthesis of Molecularly Imprinted Polymers for sorption of Mefenamic acid based on the surface of modified silica gel.
Alternative URL: http://icc2011.ir/Docs/D.pdf
Conference information: Abstracts, 15th Iranian Chemistry Congress
Abstract: Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Molecular imprinting is a technique of preparing molecularly imprinted polymers (MIPs) which can specifically recognize the imprinted template molecules. In this work silica gel was used as supporting matrix, mefenamic acid as template. 2, 2'-azo-bis-isobutyronitrile (AIBN) as the initiator, N,N-Dimetylacrylamide (DMAA), Allyl glycidil eather/iminodiacetic acid (AGE-IDA) were polymerized and grafted onto modified silica gel surface and was characterized by FT-IR, and thermogravimetric (TGA) analysis. The effect of different parameters, such as PH, amount of adsorbent , recovery, adsorption capacity of adsorbent at optimum conditions and interfering species were investigated. This modified support was used for pre-concentration and subsequent determination of mefenamic acid by high-performance liquid chromatography (HPLC) in drug capsules
Template and target information: Mefenamic acid
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