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Reference type: Book Chapter
Authors: Rosellini E, Cristallini C, Barbani N, Giusti P
Publication date: 2011
Chapter title: Engineering of Multifunctional Scaffolds for Myocardial Repair Through Nanofunctionalization and Microfabrication of Novel Polymeric Biomaterials.
Page numbers: 187-214.
DOI: 10.1007/8415_2010_42

Book title: Myocardial Tissue Engineering
Editors: Boccaccini AR, Harding SE
Publisher: Springer Berlin Heidelberg
ISBN: 978-3-642-18056-9
Series title: Studies in Mechanobiology, Tissue Engineering and Biomaterials
Volume number: 6

Abstract: In this chapter the authors provide an overview of their research activity in the field of myocardial tissue engineering, focusing on the development of bioactive scaffolds able to guide cardiac tissue formation from dissociated stem cells. The chapter describes the preparation and characterization of new bioartificial polymeric systems, which are blends of natural polymers and a novel thermosensitive and bioresorbable copolymer. The functionalisation of selected polymers using different approaches is presented: surface modification by signalling peptides, application of bioactive molecules release systems and introduction of specific recognition sites by Molecular Imprinting technology. The processing steps to develop highly porous structures, injectable microspheres and innovative scaffolds resembling the cardiac extracellular matrix architecture are further described. Finally, results are presented in the context of the development of scaffolds with multifunctional properties for guiding stem cell plasticity towards myocardial regeneration
Template and target information: Review - Tissue repair


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