MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Wang J, Banerji S, Menegazzo N, Peng W, Zou QJ, Booksh KS
Article Title: Glucose detection with surface plasmon resonance spectroscopy and molecularly imprinted hydrogel coatings.
Publication date: 2011
Journal: Talanta
Volume: 86
Issue: (1)
Page numbers: 133-141.
DOI: 10.1016/j.talanta.2011.08.046
Alternative URL: http://www.sciencedirect.com/science/article/pii/S003991401100765X

Abstract: Molecularly imprinted hydrogel membranes were developed and evaluated for detection of small analytes via surface plasmon resonance spectroscopy. Imprinting of glucose phosphate barium salt into a poly(allylamine hydrochloride) network covalently bound to gold surfaces yielded a selective sensor for glucose. Optimization of relative amounts of chemicals used for preparation of the hydrogel was performed to obtain highest sensitivity. Addition of gold nanoparticles into the hydrogel matrix significantly amplified its response and sensitivity due to the impact of gold nanoparticles on the refractive index of the sensing layer. Evaluation of its selectivity showed that the sensor displayed preferential recognition to glucose compared to structurally related sugars in addition to being unaffected by phosphate as well as compounds containing amine groups, like creatinine. The detection limit of glucose in deionized water was calculated to be 0.02 mg/mL. The developed sensor was finally exposed to human urine spiked with glucose illustrating the coating's ability to re-bind the analyte in complex matrices. While the working concentration range in water was determined to be suitable for glucose monitoring in diabetic individuals at physiological levels, the detection in urine was determined to be 0.12 mg/mL. The decreased performance in urine provided an initial perspective on the difficulties associated with measurements in complex media
Template and target information: glucose phosphate barium salt, glucose
Author keywords: surface plasmon resonance, molecular imprinting, hydrogel, gold nanoparticles, Glucose sensing

  MIPs are Forever spoof movie poster mug  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner