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Reference type: Journal
Authors: Lian WJ, Liu S, Yu JH, Xing XR, Li J, Cui M, Huang JD
Article Title: Electrochemical sensor based on gold nanoparticles fabricated molecularly imprinted polymer film at chitosan-platinum nanoparticles/graphene-gold nanoparticles double nanocomposites modified electrode for detection of erythromycin.
Publication date: 2012
Journal: Biosensors and Bioelectronics
Volume: 38
Issue: (1)
Page numbers: 163-169.
DOI: 10.1016/j.bios.2012.05.017
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566312003107

Abstract: A molecularly imprinted electrochemical sensor was fabricated based on gold electrode decorated by chitosan-platinum nanoparticles (CS-PtNPs) and graphene-gold nanoparticles (GR-AuNPs) nanocomposites for convenient and sensitive determination of erythromycin. The synergistic effects of CS-PtNPs and GR-AuNPs nanocomposites improved the electrochemical response and the sensitivity of the sensor. The molecularly imprinted polymers (MIPs) were prepared by HAuCl4, 2-mercaptonicotinic acid (MNA) and erythromycin. Erythromycin and MNA were used as template molecule and functional monomer, respectively. They were first assembled on the surface of GR-AuNPs/CS-PtNPs/gold electrode by the formation of Au-S bonds and hydrogen-bonding interactions. Then the MIPs were formed by electropolymerization of HAuCl4, MNA and erythromycin. The sensor was characterized by cyclic voltammetry (CV), scanning electron microscope (SEM), UV-visible (UV-vis) absorption speactra and amperometry. The linear range of the sensor was from 7.0 x 10-8 mol/L - 9.0 x 10-5 mol/L, with the limit of detection (LOD) of 2.3 x 10-8 mol/L (S/N=3). The sensor showed high selectivity, excellent stability and good reproducibility for the determination of erythromycin, and it was successfully applied to the detection of erythromycin in real spiked samples
Template and target information: erythromycin
Author keywords: Electrochemical sensor, Molecularly imprinted polymers, Graphene-gold nanoparticles composites, Chitosan-platinum nanoparticles composites, Erythromycin detection

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