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Abstract: This study describes the design and synthesis of molecularly imprinted polymers (MIPs) as patterned thin films, based on molecular modelling of functional monomer-template interactions and validation by NMR-spectroscopy. MIPs were prepared by dissolving the specific template and functional methacrylate monomer at varying ratios with a cross-linker and initiator in a porogenic solvent, spin-coating the solution onto 3-(trimethoxysilyl)propyl methacrylate-functionalised silicon wafers and photo-polymerisation. After template extraction, the film thickness and topography were characterised with atomic force microscopy. A 4-vinylpyridine-MIP thin film layer was then deposited by photo-lithographic etching onto this polymerised methacrylic acid MIP thin film, resulting in a grid-patterned surface in which two different MIPs alternated at a micron scale. Selectivity differences towards fluorescent template analogues were documented using fluorescence microscopy. This side-by-side comparison on the same thin film allows fast and cost-effective assessment of MIP selectivities with various biomolecules
Template and target information: N-boc-L-phenylalanine
Author keywords: Molecularly imprinted polymers, Molecular self-assembly, molecular modelling, Spin-coating, Photolithography, atomic force microscopy, Nano-structured biomimetic thin film