Authors: Arvand M
, Fallahi P
Man-Tailored Biomimetic Sensor of Molecularly Imprinted Materials for the Potentiometric Measurement of Rivastigmine in Tablets and Biological Fluids and Employing the Taguchi Optimization Methodology to Optimize the MIP-Based Membranes.
Publication date: 2012
Abstract: This work proposes a novel biomimetic sensor for the potentiometric transduction of rivastigmine based on molecularly imprinted polymer (MIP). Using the Taguchi method, this study analyzed the optimum conditions for preparing the MIP-based membranes. The rank order of each controllable factor was also determined. MIP-based membranes exhibited a Nernstian response (30.7 ± 1.1 mV decade-1) in a concentration range from 1.0 x 10-5 to 1.0 x 10-2 mol L-1 with a LOD of 6.3 x 10-6 mol L-1. The sensor was successfully applied to the determination of rivastigmine concentrations in human serum, plasma, urine, rat brain and tablets
Template and target information: rivastigmine
Author keywords: Rivastigmine, Molecularly-imprinted sensors, Taguchi method, biological fluids
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