MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Alizadeh T, Ganjali MR, Akhoundian M
Article Title: Fabrication of an Extra Sensitive Voltammetric Sensor Using Nanoparticles of Molecularly Imprinted Polymer for Determination of Ultra-Trace Promethazine in Plasma Sample.
Publication date: 2012
Journal: International Journal of Electrochemical Science
Volume: 7
Issue: (11)
Page numbers: 10427-10441.
Alternative URL: http://electrochemsci.org/papers/vol7/71110427.pdf

Abstract: In this work, the nanoparticles of promethazine-imprinted polymers (MIP) were synthesized by the ultrasonic assisted suspension polymerization in silicon oil. The MIP particles were then embedded in a carbon paste (CP) electrode in order to prepare the MIP (nano)-CP electrode. This electrode showed higher response to analyte, compared to the carbon paste electrode, modified with non-imprinted polymer (NIP (nano)-CP). Also, the sensitivity and selectivity of the MIP (nano)-CP were considerably better than those of the sensor prepared by the bulky MIP particles (MIP (micro)-CP). Various factors, known to affect the response behavior of selective electrode, were investigated and optimized. The sensor exhibited two distinct linear response ranges of 4 x 10-12 - 1 x 10-10 M and 1 x 10-9 - 1 x 10-7 M with the sensitivities of 31.7 and 0.17 μA nM-1, respectively. The lower detection limit of the sensor was calculated equal to 2.8 x 10-12 M (S/N). An interestingly low RSD equal to 0.81% was found for 5 separate determinations by the proposed sensor. The sensor was applied for promethazine (PMZ) determination in plasma samples without applying any sample pretreatment.
Template and target information: promethazine, PMZ
Author keywords: Ultratrace, molecularly imprinted polymer, nanoparticles, suspension polymerization, silicon oil, Promethazine

  Periodic table Soup - the chemical formula for soup soup mug  Periodic table Bag bag  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner