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Reference type: Journal
Authors: Prasad BB, Pandey I
Article Title: Electrochemically imprinted molecular recognition sites on multiwalled carbon-nanotubes/pencil graphite electrode surface for enantioselective detection of d- and l-aspartic acid.
Publication date: 2013
Journal: Electrochimica Acta
Volume: 88
Page numbers: 24-34.
DOI: 10.1016/j.electacta.2012.10.095
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0013468612017094

Abstract: Molecularly imprinted polymeric nano-materials (thickness 2.03 nm) for aspartic acid enantiomers were electrochemically synthesized onto multi-walled carbon nanotubes immobilized pencil graphite electrode surface. The molecular recognition in this work was based on doping/de-doping characteristics of the conducting polymer, poly (indole-3-acetic acid), wherein the template (aspartic acid) acted as a dopant which could easily be ejected from the polymer backbone after over-oxidation. This resulted in molecular cavities complementary to the template in the imprinted polymer texture. The transduction was made via differential pulse anodic stripping voltammetric detection of d- and l-aspartic acid using respective sensors. The detection limits (S/N = 3) for d- and l-aspartic acid were found to be 0.025 and 0.016 μM, respectively in aqueous solutions. Enantioselective analysis of l-aspartic acid was validated in real samples that suggested practicability of the proposed sensor for the evaluation of this bioactive molecule as a disease biomarker in clinical settings, without any cross-reactivity and false-positives
Template and target information: aspartic acid
Author keywords: Doping, de-doping, molecularly imprinted polymer, d- and l-Aspartic acid, electropolymerization, Poly (indole-3-acetic acid)


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