Abstract: A molecularly imprinted polymer (MIP) for nimodipine was prepared by bulk polymerization method, utilizing methacrylic acid (MAA) as functional monomer, trimethylol propane triacrylate (TMPTA) as cross-linking agent. The selective recognition characteristics of MIP for nimodipine, nitrendipine and felodipine drug molecules were studied in equilibrium binding experiment. The static adsorption distribution coefficient (KD) values of the three drugs were 0.221 4, 0.197 2 and 0.051 4, respectively. The results showed that MIP had a high affinity and selectivity to nimodipine. Type I adsorption isotherm was obtained by determining the adsorptive capacity at different temperatures, and an exothermic process was confirmed by the change of adsorption capacity with temperature. To further study the adsorption mechanism of the imprinted polymer and its thermodynamic properties, the changes of entropy, enthalpy and Gibbs free energy were estimated in the adsorption process at different temperature. The results showed that the adsorption process of imprinted polymer was controlled by enthalpy.
Template and target information: nimodipine
Author keywords: nimodipine, molecular imprinted polymers, thermodynamic, adsorption