MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Zhang J, Fu Q
Article Title: Preparation of ephedrine molecularly imprinted monolithic columns.
Publication date: 2006
Journal: Chinese Journal of Pharmaceutical Analysis
Volume: 26
Issue: (12)
Page numbers: 1760-1764.
Alternative URL: http://file.lw23.com/9/9f/9ff/9ff47500-5a3f-415b-8bdd-9a0bdb8ca652.pdf

Abstract: Objective: To prepare a monolithic molecularly imprinted polymer(mMIP) with specific recognition ability for the ephedrine molecule. Method: An ephedrine molecularly imprinted monolithic column was prepared by in situ polymerization using methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EDMA) as a cross—linking agent, toluene and dodecanol as porogenic solvents, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator. Results: The synthesis condition was optimized. The results showed the best ratio of template and functional monomer was 1:2 and the toluene content in porogen was 20—25%. Scanning electron microscopy and mercury intrusion porosimetry were used to identify the structural features of the mMIP. Results show the presence of three types of pore structure.The large through-pore structure allows mobile phase to flow through the column of mMIP at a low back pressure and the others may lead to the molecular recognition. Some chromatographic conditions such as the pH and the composition of the mobile phase were characterized. Conclusion: The ephedrine molecularly imprinted monolithic polymer has specific recognition ability for the ephedrine molecule. The ephedrine and pseudoephedrine were to be separated under optimized conditions.
Template and target information: ephedrine
Author keywords: molecularly imprinted polymer, Ephedrine, Pseudoephedrine, In situ technique


  Periodic table Crab Cakes - the chemical formula for a fishy snack shirt  Periodic table Bag bag  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner