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Reference type: Journal
Authors: Prasad BB, Pandey I
Article Title: Molecularly imprinted polymer-based piezoelectric sensor for enantio-selective analysis of malic acid isomers.
Publication date: 2013
Journal: Sensors and Actuators B: Chemical
Volume: 181
Page numbers: 596-604.
DOI: 10.1016/j.snb.2013.02.060
Alternative URL: http://www.sciencedirect.com/science/article/pii/S092540051300186X

Abstract: A quartz crystal microbalance sensor, having enantio-selective ability to analyze malic acid enantiomers with high sensitivity, was fabricated using a biomimetic ultra-thin film of molecularly imprinted polymer. Such material could be termed as ''glyco-molecularly imprinted polymer'' since it was synthesized using sugar moiety, adopting non-covalent self-assembly process and subsequent photo-polymerization. The piezoelectric sensor modification via ''surface-grafting from'' was found to be superior to response better than the physical entrapment of imprinted particles. The glyco-imprinted polymer sensor demonstrated exclusive specificity for l-malic acid, concomitantly present with d-malic acid and respective analogs. The rational design of malic acid/glyco-monomer complex, with composition 1:2, was predicted on the basis of theoretical modeling. The detection limit of l-malic acid was realized as 0.18 - 0.21 ng mL-1 (S/N = 3, confidence level 95%) for l-malic acid and the linearity was observed within its concentration range 20 - 210 ng mL-1, at pH 7.0, in aqueous and real samples. The proposed sensor demonstrated a fast, reliable, enantio-selective and quantitative response to malic acid isomers, in real samples
Template and target information: malic acid
Author keywords: d- and l-malic acid, molecular imprinted polymer, quartz crystal microbalance, Enantio-selective sensor

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