MIPdatabase
Authors: Adbo K, Nicholls IA
Article Title: Enantioselective solid-phase extraction using Tröger's base molecularly imprinted polymers.
Publication date: 2001
Journal: Analytica Chimica Acta
Volume: 435
Issue: (1)
Page numbers: 115-120.
DOI: 10.1016/S0003-2670(01)00913-8
Abstract: Molecularly imprinted polymers (MIPs) selective for Troger's base were designed and synthesised, and HPLC-chromatographic evaluation of polymer recognition characteristics was undertaken. Baseline separation of racemic Troger's base was readily achieved, and enantioseparation factors (alpha) of up to 4.8 +/- 0.2 were obtained. The high enantioselectivity demonstrated by these materials prompted their use to examine the kinetics and thermodynamics of individual enantiomers in a solid-phase extraction (SPE) process. Enantiomer-dependent differences in the rates and extent of adsorption were observed. Furthermore, the enantiomeric enrichment of racemates was demonstrated in batch studies. (C) 2001 Elsevier Science B.V. All rights reserved
Template and target information: Tröger's base, Troger's base, 2,8-dimethyl-6H,12H-5,11-methanodibenzo[b, f ][1,5]diazocine
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