Authors: Ramström O
, Nicholls IA
, Mosbach K
Synthetic peptide receptor mimics - highly stereoselective recognition in noncovalent molecularly imprinted polymers.
Publication date: 1994
Journal: Tetrahedron: Asymmetry
Alternative URL: http://www.sciencedirect.com/science/article/pii/0957416694800278
Abstract: Ligand-receptor recognition has been studied in a molecularly imprinted polymer (MIP) prepared against N-Ac-L-Phe-L-Trp-OMe. The non-ionic non-covalent interaction based recognition was evaluated using the polymers as chiral HPLC stationary phases. Marked regio-, enantio- and diastereo- ligand selectivity were demonstrated with enantiomer separation Factors of up to 17.8. The interaction of a series of related structures with the MIP receptor site has provided insight concerning its nature and the recognition mechanisms
Template and target information: N-Ac-L-Phe-L-Trp-OMe
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