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Reference type: Journal
Authors: Ramström O, Ye L, Mosbach K
Article Title: Artificial antibodies to corticosteroids prepared by molecular imprinting.
Publication date: 1996
Journal: Chemistry & Biology
Volume: 3
Issue: (6)
Page numbers: 471-477.
DOI: 10.1016/S1074-5521(96)90095-2

Abstract: Background: Molecular imprinting can be used to prepare antibody and receptor mimics. We have previously shown that acrylic acid polymers can be imprinted to recognize a variety of small molecules. Here, we show that molecularly imprinted polymers (MIPs) can selectively recognize steroid structures. Results: Artificial antibodies mimicking the binding performance of natural anti-corticosteroid antibodies have been prepared using a molecular imprinting protocol with either cortisol or corticosterone as a target molecule. The binding characteristics of a range of structurally related ligands were estimated using a form of radioimmunoassay. The antibody mimics were found to be highly selective for the ligands used in their preparation and the cross- reactivities with compounds of related structure resembled those obtained in studies with natural antibodies. Conclusions: The binding properties of MIPs, prepared against corticosteroids, exhibit strong similarities to those of naturally raised antibodies. Such artificial antibodies may serve as a useful complement to their natural counterparts in studies of corticosteroid binding events


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