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Reference type: Journal
Authors: Kubo T, Kuroda K, Tominaga Y, Naito T, Sueyoshi K, Hosoya K, Otsuka K
Article Title: Effective determination of a pharmaceutical, sulpiride, in river water by online SPE-LC-MS using a molecularly imprinted polymer as a preconcentration medium.
Publication date: 2014
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 89
Page numbers: 111-117.
DOI: 10.1016/j.jpba.2013.10.040
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0731708513004998

Abstract: We report an effective and a quantitative analysis method for one of pharmaceuticals, sulpiride, in river water by online solid phase extraction (SPE) connected with liquid chromatography-mass spectrometry (LC-MS) using a molecularly imprinted polymer as a preconcentration medium. The polymer prepared with a pseudo template molecule showed the selective retention ability based on the interval recognition of functional groups in sulpiride. Also, the imprinted polymer provided an effective concentration of a trace level of sulpiride in offline SPE with dual washing processes using water and acetonitrile, although another imprinted polymer prepared by an authentic method using sulpiride and methacrylic acid as a template and a functional monomer, respectively, showed the selective adsorption only in organic solvents. Furthermore, we employed the imprinted polymer as the preconcentration column of online SPE-LC-MS and the results supposed that the proposed system allowed the quantitative analysis of sulpiride with high sensitivity and recovery (10 ng/L at 96%). Additionally, the determination of sulpiride in real river water without an additional spiking was effectively achieved by the system
Template and target information: 4,4-bis-(tributylammonium-methyl chloride)biphenyl, BTAB, sulpiride
Author keywords: molecular imprinting, Interval recognition, solid phase extraction, pharmaceutical, Sulpiride

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