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Reference type: Journal
Authors: Li SJ, Cao SS, Whitcombe MJ, Piletsky SA
Article Title: Size matters: Challenges in imprinting macromolecules.
Publication date: 2014
Journal: Progress in Polymer Science
Volume: 39
Issue: (1)
Page numbers: 145-163.
DOI: 10.1016/j.progpolymsci.2013.10.002
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0079670013001238

Abstract: A large number of molecularly imprinted polymers (MIPs) have been investigated and reported over the last decade. Various templates have been successfully exploited and used, leading to significant advances in separation, adsorption, catalysis, sensing, and drug delivery. Among all the templates, small molecules have dominated in the synthesis of MIPs. In contrast, progress made in imprinting macromolecules has been slow, mainly due to the challenges presented by the size, structure and conformational fragility of biological macromolecules. In this review, we focus on discussing some key issues involved in the imprinting of macromolecules from recent publications. The similarity and difference between imprinting small molecules and macromolecules are highlighted. Other aspects relating to polymer design and function are also discussed
Template and target information: Review - MIPs for macromolecules
Author keywords: molecular imprinting, Macromolecular template, Size limitation


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