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Reference type: Journal
Authors: Wang H, Wang RL, Han YH
Article Title: Preparation of molecular imprinted microspheres based on inorganic-organic co-functional monomer for miniaturized solid-phase extraction of fluoroquinolones in milk.
Publication date: 2014
Journal: Journal of Chromatography B
Volume: 949-950
Page numbers: 24-29.
DOI: 10.1016/j.jchromb.2013.10.042
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023213006028

Abstract: An inorganic-organic co-functional monomer, methacrylic acid-vinyltriethoxysilan (MAA-VTES) was designed for the synthesis of molecularly imprinted microspheres (MIMs). By virtue of the aqueous suspension polymerization and dummy template (pazufloxacin), the obtained MAA-VTES based MIMs exhibited good recognition and selectivity to fluoroquinolones (FQs), and were successfully applied as selective sorbents of a miniaturized home-made solid phase extraction device for the determination of ofloxacin (OFL), lomefloxacin (LOM) and ciprofloxacin (CIP) in milk samples. Under the optimum conditions of the miniaturized molecularly imprinted solid phase extraction (mini-MISPE) coupled with liquid chromatography-ultraviolet detector (LC-UV), good linearities were obtained for three FQs in a range of 0.2-20.0 μg mL-1 and the average recoveries at three spiked levels were ranged from 87.2% to 106.1% with the relative standard deviation (RSD) less than 5.4%. The presented co-functional monomer based mini-MISPE-LC-UV protocol introduced the rigidity and flexibility of inorganic silicon materials, exhibited excellent extraction performance towards targets, and could be potentially applied to the determination of FQs in milk samples
Template and target information: fluoroquinolines, FQs, dummy template, pazufloxacin, ofloxacin, OFL, lomefloxacin, LOM, ciprofloxacin, CIP
Author keywords: Inorganic-organic co-functional monomer, molecularly imprinted microspheres, Home-made solid-phase extraction, Fluoroquinolones, Milk samples


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