Inventors: Irving E, Brown S, Turner NJ, Flitsch SL, Lins R
Patent Title: Method of producing dynamic combinatorial libraries
Publication date: 2003
Publication number: WO03086612

Abstract: The present invention relates to a method of producing a dynamic combinatorial library of chemical compounds. In particular, the present invention relates to a method of producing a dynamic combination of compounds containing at least one chemical entity having an arrangement of functional groups that renders it capable of binding to a molecular target, said entity being generated through the interaction of enzymes with appropriate substrates under conditions suitable for both formation and cleavage of chemical bonds. The presence of the molecular target results in an equilibrium redistribution in favour of the entity or entities interacting with said molecular target. Thus, the entity or entities interacting with the molecular target, in particular the entity or entities interacting most strongly with the target, may be identified and, if necessary, characterised.
URL: http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO03086612&F=0