Abstract: In this work, we developed a novel approach to the preparation of molecularly imprinted polymer (MIP) coatings directly onto magnetic multicore nanoparticles (MMCs) by using alternating magnetic fields (AMFs) to trigger the polymerization reaction. MIPs were synthetized with rhodamine 123 (R123) as model template molecule, methacrylic acid (MAA) as functional monomer and trimethylolpropane trimethacrylate (TRIM) as cross-linker. The amount of iron oxide nanoparticles and the composition of the polymerization mixture were optimized to enable the thermal polymerization of a thin MIP shell on each MMC by using electromagnetic heating without altering the properties of the recognition layer. The thickness of the polymerized MIP layer grafted onto the MMCs was fine-tuned by adjusting the dose of electromagnetic field (101.4 kHz, total power dissipation = 105 W). The resulting magnetic multicore MIP nanoparticles (MMC-MIPs) were characterized by FT-IR and X-ray diffraction spectroscopy, transmission electron microscopy and dynamic light scattering