Abstract: A double template imprinted polymeric membrane (DIPM) was fabricated using a surface polymerization technique on a poly(vinylidene fluoride) PVDF membrane using Quercetin (Qu) and Caffeic acid (CA) as the templates, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 4-vinylpyridine (4-VP) as the functional monomer via a thermal polymerization process. The polymerization of the imprinted membrane was characterized and optimized using critical variables such as concentration functional monomer and cross-linker for double responses on simultaneous binding capacity for Qu and CA using a central composite design (CCD). The optimized parameters were obtained from the concentration monomer and cross-linker at 4 mmol and 20 mmol, respectively; with the highest binding capacity for Qu (0.735 mg/g) and CA (1.1485 mg/g) achieved. The batch binding studies were conducted and simultaneous binding capacity showed that the DIPM obtained the highest Qu (4.3807 mg/g) and CA (4.0742 mg/g) adsorption at 24 mg/L when compare to NIM, followed by the Langmuir and Freundlich models, respectively. Finally, the imprinting factor (IF), selectivity (α), and distribution coefficient (KD) of DIPM showed the highest Qu and CA adsorption when compared to its competitive components and NIM. The simultaneous binding performance studies have proven that a double imprinted membrane ability in recognition and adsorption for the desired template