Abstract: Iron (Fe) is an essential mineral, but iron overload can reason in multiple organ failures and cell injury. Iron overload syndromes can be widely classified as hereditary hemochromatosis. The development of iron overload is seen in hereditary hemochromatosis, a common inherited disorder that may lead to progressive organ dysfunction including cirrhosis, arthritis, hypogonadism, diabetes mellitus, and cardiomyopathy. If patients with iron overload are not treated, their life expectancy will be shortened. Nanochelators are usually utilized to remove overload iron. Many novel nanochelator have been formulated for effective methods. The ion molecular imprinting is a technique to form recognition sites in the highly cross-linked polymer using a template ion. In this research, effective ion-imprinted polymer-based nanoparticles were synthesized and evaluated for selective removal of iron(III). The iron-imprinted nanoparticles were prepared by using functional monomer N-methacryloyl-l-glutamic acid (MAGA) and comonomer 2-hydroxyethyl methacrylate by mini-emulsion polymerization techniques. The template analyte was desorbed with 0.01 M EDTA desorption agent. The iron-imprinted nanoparticles were selective for Fe(III) toward other analogs (Zn(II), Cr(III) and Al(III)). The adsorption isotherm model fitted the Langmuir isotherm with 0.995 of R2 value and the 83.33 mg/g of Qmax value for the Fe(III)-imprinted nanoparticles. The values of separation factor (RL) were found to be 0.016 for Fe(III). The maximum binding capacity for the ion-imprinted nanoparticles was found to be 77.80 mg/g dry nanoparticles, which is 8.9 times higher than the non-imprinted nanoparticles under the same conditions. Synthetic gastric fluid experiments were also performed for Fe(III) removal
Author keywords: Beta Thalassemia, iron removal, ion-imprinted polymers, Nanochelators