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Reference type: Journal
Authors: Puig SF, Fraga ARL, Korgel BA, Oza G, Dutt A, Becerra VV, Gonz�lez ACV, Ram�rez AUC
Article Title: Molecularly Imprinted Polymer-Silica nanocomposite based Potentiometric sensor for early prostate cancer detection.
Publication date: 2021
Journal: Materials Letters
Article Number: 131324.
DOI: 10.1016/j.matlet.2021.131324
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0167577X2102022X

Abstract: A novel nanocomposite based on molecularly imprinted polymer (MIP) polymerized over silica nanoparticles (Si) is used for the development of an all-solid-state (ASS) potentiometric sensor for determination of sarcosine, a biomarker for Prostate Cancer (PCa). This MIP-Si sensor has shown high selectivity in phosphate-buffered solution (PBS) and simulated body fluid (SBF). We have obtained a linear response (10-5 - 10-8 mol/L), with a low detection limit (7.8 × 10-8 mol/L) and a quick response time close to 30 s, being stable for at least 150 days. It is corroborated that the sensor is a stable, reproducible, and sensitive biosensing device for PCa detection
Author keywords: Sarcosine, potentiometric ASS sensor, Molecularly imprinted polymer

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