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Abstract: The molecular imprinted polymer (MIP) with high selectivity to di(2-propylheptyl) phthalate (DPHP) was synthesized by precipitation polymerization with dioctyl phthalate (DOP) as dummy template, methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker. Using the prepared MIP as a solid-phase extraction (SPE) sorbent, the effects of the type and amount of elution solvents on the recovery of DPHP were investigated. After optimization of SPE profile,the DPHP extraction recovery of 96.8% was obtained when the following procedure was applied to MIPs cartridge: conditioning with 2 mL methanol, loading with 1 mL methanol,washing with 1 mL methanol-water ( 9:1,V/V),eluting with 5 mL methanol-acetic acid ( 9:1,V/V). The recovery of DPHP on NIPs cartridge was only 52.9%. The developed MISPE-HPLC method was applied to determine the concentrations of DPHP in rabbit serum at different time points after oral administration. It was found that cmax and tmax were 5.88 μg/mL and 4 h, respectively. The recoveries of spiked DPHP in rabbit serum ranged from 90.5%~91.8%. The relative standard deviation is less than 5%
Template and target information: di(2-propylheptyl) phthalate, DPHP
Author keywords: Di(2-propylheptyl) phthalate, dummy template, molecular imprinted polymer, Solid-phase extraction, Rabbit serum