MIPdatabase
Authors: Al-Othman ZA, Al-Warthan A, Ali I
Article Title: Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography.
Publication date: 2014
Journal: Journal of Separation Science
Volume: 37
Issue: (9-10)
Page numbers: 1033-1057.
DOI: 10.1002/jssc.201301326
Abstract: During the last decade, chiral monolithic stationary phases have been prepared and used for rapid enantioseparations in CEC and HPLC. Various chiral selectors are used to prepare these CSPs. The preparation, properties, and applications of these CSPs are discussed in this paper. Attempts have been made to describe optimization strategies and the chiral recognition mechanisms. A comparison of chiral separations in CEC and HPLC is described. Efforts have also been made to predict the future perspectives and challenges of chiral monolithic stationary phases. The most effective chiral selectors include polysaccharides, cyclodextrins, and macrocyclic glycopeptide antibiotics. These chiral phases produced acceptable analytical enantiomeric separation of a variety of racemates. However, the development of these CSPs for preparative-scale separations is needed
Template and target information: Review - monolithic chiral stationary phases
Author keywords: Chiral monolithic stationary phases, Chiral recognition mechanisms, enantioseparation, monoliths
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