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Abstract: A novel thermo-sensitive D-naproxen (D-Npx) molecularly imprinted hydrogels (MIH) was prepared by thermal polymerization with D-Npx as the template molecule, N-isopropylacrylamide as functional monomer, N,N'-methylene- bis-acrylamide and ethylene glycol dimethacrylate as cross-linking agent, respectively. The thermo-sensitivity and the influences of the cross-linking agent on structure and separation performance of the hydrogels were investigated. The results showed that the equilibrium swelling ratio of MIH decreased with the increase of the concentration of MBAA, and adsorption and desorption amount of D-Npx increased firstly and then decreased. The adsorption and desorption amount of D-Npx increased continually with the increase of the concentration of EGDMA. MIHs exhibit obvious thermo-sensitivity. The concentration of MBAA had little effect on the lower critical solution temperature (LCST) of the hydrogels, and MIHs exhibited excellent reverse swelling-deswelling property, the maximum of desorption amount of D-Npx could reach up to 90%.
Template and target information: D-naproxen, naproxen, D-Npx
Author keywords: D-naproxen, thermo-sensitivity, Molecularly imprinted hydrogels, adsorption