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Authors: Mikulska A, Inoue M, Kuroda K, Iwanowska A, Yusa SI, Nowakowska M, Szczubialka K
Article Title: Polymeric/silicagel hybrid molecularly photoimprinted adsorbents for adenosine and its derivatives.
Publication date: 2014
Journal: European Polymer Journal
Volume: 59
Page numbers: 230-238.
DOI: 10.1016/j.eurpolymj.2014.07.029
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0014305714002535
Abstract: The adsorbents of adenosine, a potential cancer biomarker present in physiological fluids, urine in particular, were obtained and studied. The adsorbents were fabricated by coating submicron-sized silica gel particles with ultrathin layers of polymers containing thymine moieties. The thymine groups selectively adsorbed compounds containing adenine, a nucleobase complementary to thymine, via the formation of hydrogen bonds. Irradiation of the adsorbents with light selectively absorbed by thymine chromophores in the presence of adenine as a template molecule resulted in the photochemical molecular imprinting of adenine. The non-imprinted adsorbent showed preferential adenosine adsorption from a solution containing a mixture of nucleosides. The adenine-imprinted materials showed considerably higher than non-imprinted adsorbents selectivity of adenosine adsorption versus other nucleosides
Template and target information: adenine
Author keywords: adenosine, adenine, thymine, adsorbents, molecular imprinting, photodimerization
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