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Abstract: The aim of this work was to test the application of multi-walled carbon nanotube based molecularly imprinted polymer (MWCNTs-MIP) for the determination of dopamine (DA) in blood serum and urine samples. The acrylamide grafted MWCNTs with vinyl group (MWCNTs-g-AAm-CHCH2) was prepared by free radical graft copolymerization technique. MIP was synthesized by selective polymerization of MWCNTs-g-AAm-CHCH2 with itaconic acid (IA) as functional monomer in the presence of DA using ethylene glycol dimethacrylate (EGDMA) as a cross-linker and α,α'-azobisisobutyronitrile (AIBN) as the initiator. The response time was ~2 min and the detection limit was 1.0 x 10-9 mol L-1, so the proposed sensor could be considered as a sensitive marker of DA depletion in Parkinson's disease. The MWCNTs-MIP sensor demonstrated a high selectivity, sensitivity and stability, in addition to that good reproducibility. The useful lifetime for the DA sensor was longer than 2 months and the sensor was successfully tested in real samples
Template and target information: dopamine, DA
Author keywords: acrylamide, dopamine, graft copolymerization