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Abstract: A technique for the creation of macromolecular binding sites is described. The sites are created by molecular imprinting, a process that utilizes a template or imprinting moleculae to organize polymerizable monomers prior to their copolymerization with crosslinking monomers. The resulting network polymers are highly crosslinked macroporous materials. Following removal of the imprinting molecule, the solid polymers are found to rebind selectively the imprinting molecule. These macromolecular binding site are being developed as diagnostics for drug assays, as microreactors for stereoselective chemical transformations, as custom chromatographic supports and as designed catalysts. In selected examples, the binding and catalytic efficiency approaches that of protein-based biological receptors and catalysts
Template and target information: Review - MIPs in binding and catalysis