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Reference type: Journal
Authors: Shi HQ, Tsai WB, Garrison MD, Ferrari S, Ratner BD
Article Title: Template-imprinted nanostructured surfaces for protein recognition.
Publication date: 1999
Journal: Nature
Volume: 398
Issue: (6728)
Page numbers: 593-597.
DOI: 10.1038/19267

Abstract: Synthetic materials capable of selectively recognizing proteins are important in separations(1), biosensors(2) and the development of biomedical materials(3-5). The technique of molecular imprinting creates specific recognition sites in polymers by using template molecules(6-9). Molecular recognition is attributed to binding sites that complement molecules in size, shape and chemical functionality(10). But attempts to imprint proteins have met with only limited success(11-15). Here we report a method for imprinting surfaces with protein-recognition sites. We use radio-frequency glow- discharge plasma deposition to form polymeric thin films(16) around proteins coated with disaccharide molecules. The disaccharides become covalently attached to the polymer film, creating polysaccharide-like cavities that exhibit highly selective recognition for a variety of template proteins, including albumin, immunoglobulin G, lysozyme, ribonuclease and streptavidin, Direct imaging of template recognition is achieved by patterning a surface at the micrometre scale with imprinted regions
Template and target information: protein, albumin, immunoglobulin G, lysozyme, ribonuclease, streptavidin


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