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Abstract: A new process was developed for the selective extraction and pre-concentration of amitriptyline (AT) from human plasma using nano-sized molecularly imprinted polymer (MIP) with ultrasound-assisted extraction (UAE). The nano-sized AT imprinted polymer particles were synthesized using suspension polymerization in silicon oil and characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscope (SEM) methods. With the application of optimized values, linearity values in the ranges of 20-200 μg mL-1 and 35-200 μg mL-1 were obtained for AT with the correlation of determination values (r2) 0.998 and 0.995 in water and plasma, respectively. The limits of detections (S/N = 3) for AT were found to be 0.7 and 1.2 μg mL-1 in water and plasma, respectively. The enrichment factors of AT in water and plasma were 52 and 40, respectively. The inter-day precisions (%) were in the range of 5.8-9.2%. Relative recovery rates ranged from 82.4% to 92.3%. The method was successfully applied to determine AT in the human plasma samples
Template and target information: amitriptyline
Author keywords: Nano-sized molecularly imprinted polymer, Amitriptyline, Ultrasound-assisted, Gas chromatography-flame ionization