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Authors: Blanco-Fernandez B, Concheiro A, Alvarez-Lorenzo C
Publication date: 2014
Chapter title: Stimuli-Sensitive Nanostructured Systems for Biomedical Applications.
Chapter number: B3
Page numbers: 309-348.
DOI: 10.1142/9789814520652_0061 Alternative URL: http://www.worldscientific.com/doi/abs/10.1142/9789814520652_0061
Book title: Handbook of Nanobiomedical Research
Editors: Torchilin V
Publisher: WORLD SCIENTIFIC
ISBN: 978-981-4520-64-5
Series title: Frontiers in Nanobiomedical Research
Volume number: 3
Abstract: Efficient and safe drug delivery to the site of action is still a challenging task. Carriers that combine single components according to a given pattern have been shown advantageous over continuous structures. Nanostructured systems try to mimic the cost-effective way that Nature uses to prepare responsive functional structures that regulate in the body the transport and recognition of endogenous and exogenous substances. This chapter focuses on self-assembly of lipids and polymers as well as other bottom-up strategies (e.g. molecular imprinting) that render stimuli-responsive nanostructured particles with a variety of morphologies and capabilities. Applications as self-regulable and externally-tunable drug delivery systems are revisited with a particular attention on the performance under in vivo conditions
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