Authors: Poma A
, Brahmbhatt H
, Pendergraff HM
, Watts JK
, Turner NW
Generation of Novel Hybrid Aptamer-Molecularly Imprinted Polymeric Nanoparticles.
Publication date: 2015
Journal: Advanced Materials
Abstract: A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified "aptamer monomer" results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility
Template and target information: benzoylecognine, BEC, cocaine
Author keywords: Aptamers, Cocaine, Molecularly imprinted polymers, nanoparticles, solid-phase synthesis
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