MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Suksuwan A, Lomlim L, Rungrotmongkol T, Nakpheng T, Dickert FL, Suedee R
Article Title: The composite nanomaterials containing (R)-thalidomide-molecularly imprinted polymers as a recognition system for enantioselective-controlled release and targeted drug delivery.
Publication date: 2015
Journal: Journal of Applied Polymer Science
Volume: 132
Issue: (18)
Page numbers: Article No 41930.
DOI: 10.1002/app.41930

Abstract: A molecularly imprinted polymer (MIP) enantioselective receptor for the (R)-thalidomide enantiomer was synthesized and evaluated for its ability to deliver the drug to cancer cells. Polymer networks with precisely engineered binding sites were built into the assembled nanoparticles by a self-organizing template in the prepolymerized mixture using methacrylic acid, a fluorescently active 2,6-bis(acrylamido)pyridine and N,N' methylene-bis-acrylamide, via both a covalent approach and a physical approach. The fine-tuning of particle diameters was carried out by changes to the polymerizing synthesis method, the type of solvent and the amount of the poloxamer that led to an optimal formulation of the nanoparticles with sizes as small as 100 nm. Data from the 1H-nuclear magnetic resonance spectroscopy revealed the important structural motifs of an (R)-thalidomide-selective cavity for two different polymerization processes. We have investigated their ability for enantiomer recognition and the potential ability to protect the chiral MIP with a self-assembled poloxamer structure. Moreover, the effect of the smaller molecular size can not only enable favorable imaging properties but also facilitate enhanced green fluorescence intensity for the deposited MIP and the (R)-thalidomide in the poloxamer nanoparticles in a cell-line in which the grafted MIP being higher than the deposited one. It was also demonstrated that the deposited MIP nanoparticles had the potential to make the drug effective for attacking multidrug-resistant cells. Thus, the poloxamer nanoparticles containing a thermoresponsive MIP could maximize the release of the nontoxic (R)-thalidomide at the tumor tissue, with the help of a proper temperature shift at the site. 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41930
Template and target information: (R)-thalidomide, thalidomide
Author keywords: biomimetic, molecular recognition, self-assembly, stimuli-sensitive polymers


  Periodic table Nerd shirt  Cryptic logo shirt  Woman of proper-tea mug in red

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon