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Abstract: Hollow molecular imprinted polymer microspheres were prepared by distillation precipitation polymerization with (S)-(+)-ibuprofen (S-IBF) as template molecule and acrylamide (AM) as functional monomer. Using the silicon dioxide (SiO2, 180 nm) modified by 3-(trimethoxysilyl)propyl methacrylate (MPS) as the template microspheres, the molecular imprinted shells were coated on successfully (SiO2@MIPs). The thermosensitive SiO2@MIPs-PNIPAM core-shell microspheres were subsequently prepared by grafting the PNIPAM chains (Mn = 1.21 x 10^4 g/mol, polydispersity index=1.30), which were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, on the surface of SiO2@MIPs microspheres via the thiol-ene click chemistry. The grafting density of PNIPAM brushes on the SiO2@MIPs microspheres was about 0.18 chains/nm2. After HF etching, the hollow imprinted microspheres were finally obtained. For thermosensitivity analysis, the phase transition temperatures of multifunctional nanoparticles were measured by DSL at 25 °C and 45 °C respectively, and the sizes of the microspheres changed by about 35 nm. The modified microspheres presented excellent controlled release property to S-IBF, moreover about half amount of the adsorptions passed into acetonitrile-water solution through the specific holes of imprinted shell at 25 °C under vibration
Template and target information: ibuprofen, S-IBF, (S)-(+)-ibuprofen
Author keywords: molecular imprinted polymer microspheres, thermosensitive, ibuprofen, hollow structure, controlled release