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Reference type: Journal
Authors: Sreenivasan K
Article Title: Application of molecularly imprinted polymer as a drug retaining matrix.
Publication date: 1997
Journal: Angewandte Makromolekulare Chemie
Volume: 246
Issue: (1)
Page numbers: 65-69.
DOI: 10.1002/apmc.1997.052460105

Abstract: Copolymerization by gamma irradiation of 2-hydroxyethyl methacrylate with ethylene glycol dimethacrylate in the presence of hydrocortisone as model drug gave a molecular imprinted polymer (MIP). The hydrocortisone was removed from the matrix with chloroform and incorporated again from methanol solution. Release data show that 96% of the incorporated drug is retained after 30 days storage in a methanol/water (3:1 v/v) mixture. In comparison with hydrocortisone, only a small quantity of testosterone is absorbed by the matrix


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