Abstract: The demand for advanced, sensitive, and low-cost sensor platforms is growing. However, sensors containing biological recognition elements sometimes present restrictions, which limit their use. This work focused on the development of surface plasmon resonance (SPR) based on a molecularly imprinted polymer (MIP) film, which builds a foundation for biomimetic sensors. The MIP films in the sensor chip were prepared by spin-coating method. The MIP film was found to be readily incorporated into the sensor for detection of histamine in aqueous media. The effect of pH conditions was also investigated. The sensing technique allows for the detection of histamine in a wide range of concentration from 25 μg L-1 to 1000 μg L-1. By using structural analogs, the sensor platform was demonstrated to be specific for the detection of histamine
Template and target information: histamine
Author keywords: surface plasmon resonance sensor, histamine, molecular imprinting, biomimetic sensors