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Abstract: We describe the use of synthetic polymers imprinted with quinine as chiral stationary phases (CSPs) in thin-layer chromatography (TLC). The stereoselectivity of the molecularly imprinted polymers (MIP) obtained was investigated fur resolution both of diastereomers, including quinine-quinidine and cinchonine-cinchonidine, and of enantiomers, including pseudoephedrine, ephedrine, norephedrine, and epinephrine. The polymers, with CaSO4 as binder, were highly suitable for use as stationary phases in TLC. We found that during the imprinting process some residual print molecules were retained by the polymer with the result that the absorption of the background and of test substances an the TLC plate at lambda = 366 nm was different, which was advantageous for spot detection. These MIPs were able to resolve diastereomeric pairs of their own imprint molecule and other stereoisomers structurally related to the imprint molecule