MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Karim K, Giannoudi L, Piletska E, Chianella I, Henry OYF, Laitenberger P, Piletsky SA, Cowen T
Article Title: Development of MIP sensor for monitoring propofol in clinical procedures.
Publication date: 2015
Journal: Journal of the Chinese Advanced Materials Society
Volume: 3
Issue: (3)
Page numbers: 149-160.
DOI: 10.1080/22243682.2015.1031278
Alternative URL: https://www.researchgate.net/publication/280603031_Development_of_MIP_sensor_for_monitoring_propofol_in_clinical_procedures

Abstract: Propofol is a widely used intravenous anaesthetic which requires close patient monitoring that involves blood extraction methods. Polymers with high affinity for propofol were computationally designed and their binding affinity tested. A diethylaminoethyl methacrylate based molecularly imprinted polymer was optimised in solid-phase extraction experiments showing no cross-reactivity to injections of urea, glucose, alfentanil and morphine. These polymers were initially integrated with screen-printed electrodes by photopolymerisation and used to detect propofol amperometrically, before modification to include conductive carbon to create better communication between the recognition sites of the polymer and the electrode. The sensors exhibited excellent linearity across the relevant clinical range with a detection limit of 4.19 μM measured in the presence of highly electroactive interferents such as uric acid and ascorbic acid. The mode of operation of the sensor reported herein differs significantly from the current state of the art and opens new opportunity towards the integration of synthetic receptors as electrochemical biosensors for point-of-care applications
Template and target information: propofol, 2,6-diisopropylphenol
Author keywords: molecularly imprinted polymer, propofol, Electrochemical, sensor, nanocomposites, point-of-care


  Shirt featuring the name Sergey spelled out in symbols of the chemical elements  Mug featuring the name Iva spelled out in the single letter amino acid code  British periodic table patriotic tote bag






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner