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Reference type: Conference Proceeding
Authors: Khalilian F, Khajoei F, Tehrani RMA
Publication date: 2014
Article title: Preparation and application of graphene oxide-based sertraline-imprinted polymer on dispersive solid-phase extraction from biological samples.
Alternative URL: http://www.nanosociety-ir.com/files/cu23se2415402.pdf

Conference information: Proceedings of 5th International Congress on Nanoscience & Nanotechnology (ICNN2014)

Abstract: In this study, a graphene oxide-based imprinted polymer with sertraline as a template, methacrylic acid (MAA), γ-methacryloxypropyl trimethoxy silane (γ-MAPs) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and 2,2 azobis isobutyronitrile (AIBN) as an initiator have been prepared through the cross-link reaction of polymerization. The composite of molecularly imprinted polymer (MIPs) was fabricated onto the surface of SiO2/graphene oxide (GO) after incorporation of vinyl group to lead further polymerization reaction. The synthesized MIP has been characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and x-ray diffraction (XRD) analysis. Dispersive solid phase extraction (DSPE) procedure for the extraction of sertraline from urine and plasma samples using the prepared MIPs and non-imprinted (NIPs) was evaluated. The effect of different variables such as the sample pH of, extraction time, salt amount, sorbent amount, type and volume of eluent for desorption process were evaluated. Under optimal conditions linear dynamic range of method was 1-250 μg/L. The amount of relative standard deviation of proposed procedure was 11.1. Finally this method was applied to the determination of sertraline in plasma and urine samples and satisfactory relative recoveries were achieved.
Template and target information: sertraline
Author keywords: Graphene oxide, Sertraline-imprinted polymer, Dispersive Solid Phase Extraction, Urine and plasma samples


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