Abstract: Methacrylic acid as functional monomer, pentaerythritol triacrylate as cross-linking agent were used to prepare molecularly imprinted polymer (MIP) with the feature of specific recognition performance on imprinting molecule nimodipine under condition of template molecule nimodipine. The preparation conditions, recognition performance of MIP on nimodipine, different proportions of template molecule and functional monomer, the selectivity to other substrate, and the relationship between adsorption quantity (Q) and time were observed.
Results: MIP was prepared successfully bynimodipine as template and pentaerythritol triacrylate as cross-linking agent, with the feature of specific recognition performance on nimodipine. The static adsorption distribution coefficient (KD) was 0.2264. The equation of Q and the concentration of substrate of template MIP was y = -0.21x + 0.2204. Combining capacity of template molecule at the same concentration enhanced with the increasing proportion of functional monomer.
Template and target information: nimodipine
Author keywords: nimodipine, molecularly imprinted polymer, binding property, selectivity