MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Hashemi-Moghaddam H, Abbasi F
Article Title: Synthesis of Molecularly Imprinted Polymers Coated on Silica Nanoparticles for Removal of P-Nitrophenol from Crude Pharmaceuticals.
Publication date: 2015
Journal: Pharmaceutical Chemistry Journal
Volume: 49
Issue: (4)
Page numbers: 280-286.
DOI: 10.1007/s11094-015-1270-4

Abstract: This paper describes the preparation of molecularly imprinted polymer (MIP) layer-coated silica nanoparticles for separation and determination of p-nitrophenol from active pharmaceutical ingredients. A new MIP was synthesized using p-nitrophenol, methacrylic acid (functional monomer), MPTS (chemically modifier), silica nanoparticles, ethylene glycol dimethacrylate (cross-linker), 2,2'-azobisisobutironitril (intiator) and toluene - acetonitrile (porogenic solvent). The surface of silica nanoparticles (Si-NP) was modified by reaction with 3-)methacryloxy)propyltrimethoxylsilane. Then, MIP coated on silica nanoparticles was synthesized by copolymerization of the vinyl end groups with functional monomer, cross-linking agent, initiator, and template molecule and these particles were used for solid-phase extraction of p-nitrophenol. To compare the performance of this MIP, a control polymer or non-imprinted polymer (NIP) was prepared using the same method and same material without the template molecule. The synthesized polymers were characterized by FT-IR spectroscopy, XRD, and SEM techniques. Parameters such as adsorption time, solution pH, and type of eluent for the elution of impurities from MIP were optimized. Selectivity of the MIP for the absorption of p-nitrophenol was investigated through adsorption experiments and the results were compared with the adsorption of impurities by NIP
Template and target information: p-nitrophenol, 4-nitrophenol
Author keywords: molecularly imprinted polymer, Genotoxic impurities, pharmaceuticals, solid phase extraction


  Krypton periodic table mug  Scientist peptide mug  I shop perodically customisable tote bag






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner